METHOD FOR PRODUCING HYPOALLERGENIC MAJOR BIRCH POLLEN ALLERGENS RBET V 1

摘要

The invention relates to a method for producing hypoallergenic major birch pollen allergens by means of at least one chromatographic clean-up step, using essentially non-buffered aqueous bases as mobile solvents, followed by neutralisation. The hypoallergenic major birch pollen allergens are characterised by a lack of, or at least reduced, immunoglobulin-E binding and simultaneous therapeutically relevant T-cell stimulation. Said allergens can thus be used in specific immunotherapy as therapeutic agents having few side effects.