| 摘要 |
<p>A compound represented by the following general formula (1): Q1-Q2 -T0- N(R1)- Q3- N(R2)- T1-Q4 (1) wherein R1 and R2 represent each hydrogen, etc.; Q1 represents optionally substituted and saturated or unsaturated 5- to 6-membered cyclic hydrocarbyl, etc.; Q2 represents a single bond, etc.; Q3 represents a group -C(R3a) (R4a)- {C(R3b) (R4bm1 -{C(R3c) (R4c m2- {C(R3d) (R4d m3- {C(R3e) (R4em4 -C(R3f) (R4f)- (wherein R3a to R4e represent each hydrogen, etc.); T0 represents carbonyl, etc.; and T1 represents -COCONR-, etc.; its salt, solvates thereof or N-oxides of the same. These compounds are useful as preventives and/or remedies for cerebral infarction, cerebral embolism, myocardial infarction, angina, pulmonary infarction, pulmonary embolism, Buerger disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombosis after artificial valve/joint replacement, thrombosis and reocclusion after reconstructing blood circulation, systemic inflammatory response syndrome (SIRS), multiorgan dysfunction syndrome (MODS), thrombosis in extracorporeal circulation and blood coagulation in blood collection.</p> |
