摘要 |
The present invention relates to the field of infection and inflammation and, more specifically, to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88<SUB>S</SUB>), which has been identified encoding a protein that inhibits LPS-induced NF-kappaB activation. MyD88<SUB>S </SUB>is a target to inhibit the phenomenon of endotoxin-tolerance that occurs in sepsis.
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