| 摘要 |
Methods and compositions are described for determining the expression profile of a tumor and subsequently determining an appropriate cancer therapy. Accordingly, a database can correlate expression profile data of a particular tumor before a chemotherapeutic is administered, and after the chemotherapeutic is administered and after tumor progression, such as when a tumor has developed a resistance to the chemotherapeutic agent. The database can then be used to determine an appropriate treatment for a patient with a particular kind of tumor that expresses a particular subset of genes. The methods and compositions related to the invention can further be used to predict at least one secondary therapeutic agent, which is targeted against a gene overexpressed in tumor tissue following treatment with a primary therapy and during tumor progression.
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