发明名称 |
Mutant androgen receptor, cancer cells expressing the same, a method of producing them and use thereof |
摘要 |
The present invention provides a mutant androgen receptor (AR) useful for screening an agent for the prophylaxis/treatment of androgen-independent cancer and the like, DNA encoding the AR and the like. It also provides a method of producing a mutant AR expressing cancer cell line in vitro, a method of screening for an anti-antiandrogen drug using the mutant AR expressing cancer cell line obtained by this method, a method of classifying anti-androgen drugs, a cocktail therapy agent comprising a combination of anti-androgen drugs classified by this method and the like.
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申请公布号 |
US2005181462(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
US20040516705 |
申请日期 |
2004.12.02 |
申请人 |
HARA TAKAHITO;KUSAKA MASAMI;MIYAZAKI JUNICHI |
发明人 |
HARA TAKAHITO;KUSAKA MASAMI;MIYAZAKI JUNICHI |
分类号 |
A61K45/00;A61P5/28;A61P35/00;A61P43/00;C07K14/72;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/09;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;C12R1/91;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/574;G01N33/74;(IPC1-7):G01N33/574;C12N5/08 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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