发明名称 |
Methods for the production of sildenafil base and citrate salt |
摘要 |
Provided are processes for the preparation of sildenafil base and the citrate salt of sildenafil. Also provided are sildenafil citrate water adduct and a method of preparing pharmaceutical compositions comprising combining the sildenafil citrate and/or sildenafil citrate water adduct with at least one pharmaceutically-acceptable excipient.
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申请公布号 |
US2005182066(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
US20050030545 |
申请日期 |
2005.01.05 |
申请人 |
BRAUDE VIVIANA;ARONHIME JUDITH;SHABAT SHALOM |
发明人 |
BRAUDE VIVIANA;ARONHIME JUDITH;SHABAT SHALOM |
分类号 |
A61K31/519;C07D487/02;C07D487/04;(IPC1-7):A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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