发明名称 |
MCT1 TRANSPORTER EXPRESSED IN BLOOD BRAIN BARRIER CELLS |
摘要 |
<p>MCT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the MCT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.</p> |
申请公布号 |
WO2005075992(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
WO2004US44002 |
申请日期 |
2004.12.30 |
申请人 |
XENOPORT, INC.;ZERANGUE, NOA |
发明人 |
ZERANGUE, NOA |
分类号 |
A61K31/19;A61K31/225;A61K31/60;A61K47/48;C12Q1/68;G01N33/50;G01N33/53;G01N33/567;G01N33/68;(IPC1-7):G01N33/50;A61P25/00 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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