发明名称 |
DIUREA DERIVATIVES |
摘要 |
The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro- inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a medicament, the use of said compound for the manufacturing of a medicament for the treatment of immune disorders which benefit from inhibiti on of production of IL-2 and other pro-inflammatory cytokines and/or induction of apoptosis in activated T-cells, a pharmaceutical composition comprising said compound and a method of treatment comprising administration of a pharmaceutically effective amount of said compound. A compound of the genera l formula I.
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申请公布号 |
CA2551566(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
CA20052551566 |
申请日期 |
2005.01.19 |
申请人 |
ACTIVE BIOTECH AB |
发明人 |
ABRAMO, AINA LISBETH;PETTERSSON, LARS OLOF GOERAN;SUNDSTEDT, ASA ANETTE;ANDERSSON, KERSTIN INGALILL |
分类号 |
A61K31/4025;A61K31/155;A61K31/195;A61P19/00;A61P21/00;C07D207/26;C07D211/98;C07D213/75;C07D215/00;C07D215/38;C07D295/13;C07D401/12;C07D403/12 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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