4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE

摘要

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. Formula (I) where Q is C1-6 alkylidene chain wherein one methylene unit of Q is replaced by -C(O)N(R)-, -C(O)-, -C(O)O-, -N(R)-, -O-, -S-, -SO2-, or -SO2N(R)-; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group, wherein: two R groups on the same nitrogen atom are optionally taken together with said nitrogen atom to form an optionally substituted 3-7 membered saturated, partially unsaturated, of fully unsaturated ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R<1> is H, -N(R)2, or an optionally substituted ring selected from a 3-7 membered saturated or partially unsaturated ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 5-6 membered aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8-10 membered bicyclic partially unsaturated or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R<2> is an optionally substituted 6-membered aryl ring having 0-3 nitrogens; R<3> is R, CN, NO2, halogen, N(R)2, OR, or SR; and Ring A is an optionally substituted ring selected from formulas (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o) or (p).