SUBSTITUTED THIENYL-MERCAPTOKETONES, AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH HISTONE DEACETYLASE ENZYMATIC ACTIVITY

摘要

A compound of formula: (I): in which A represents optionally substituted monocyclic heteroaryl or phenyl; B represents optionally substituted heteroaryl, aryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl, or B represents H when L represents a single bond; L represents a single bond, alkylene, (CH2)nX(CH2)m, (CH2)nX(CH2)pY(CH2)m; X represents -O-, -NR<3>-, -CO-, -SO2-, -NR<3>CO-, -NR<3>SO2-, -CONR<3>-, -SO2NR<3>-, -NR<5>CONR<5a>-; Y represents NR<3>- or -O-; R<1> represents H, COR<8>; R<2> represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, CN; R<3> represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, or alkyl substituted by -OR<4>, -NR<5>R<6>, -NR<6>COR<7>, -NR<6>SO2R<7>, -CONR<5>R<6 >or -SO2NR<5>R<6>; R<4> represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R<5> and R<5a> represent H or alkyl; R<6> represents H, alkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl or NR<5>R<6> represents a cyclic amine; R<7> represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; R<8> represents alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; n represents 0-3; m represents 0-3; p represents 1-3; and corresponding disulphides, N-oxides, pharmaceutically acceptable salts, solvates and prodrugs thereof; and use to treat a disease in which inhibition of histone deacetylase can prevent, inhibit or ameliorate the pathology and/or symptomatology of the disease.