发明名称 |
PEPTIDYL ARGININE DEIMINASE TYPE IV INHIBITOR |
摘要 |
<p>A compound represented by the following general formula (I) or a salt thereof. [Chemical formula 1] (I) (In the formula, R<1>, R<2>, and R<3> each independently represents hydrogen or C1-3 alkyl, provided that at least one of R<1>, R<2>, and R<3> is not hydrogen; R<4> represents substituted amino; and R<5> represents optionally substituted carboxy.) Also provided is a peptidyl arginine deiminase type IV inhibitor. With this inhibitor, diseases in which a peptidyl arginine deiminase participates (e.g., articular rheumatism and multiple sclerosis) can be prevented and/or treated.</p> |
申请公布号 |
WO2005075414(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
WO2005JP01574 |
申请日期 |
2005.02.03 |
申请人 |
YOKOHAMA CITY UNIVERSITY;SATO, MAMORU;SHIMIZU, TOSHIYUKI;HASHIMOTO, HIROSHI;YAMADA, MICHIYUKI;HIDAKA, YUJI |
发明人 |
SATO, MAMORU;SHIMIZU, TOSHIYUKI;HASHIMOTO, HIROSHI;YAMADA, MICHIYUKI;HIDAKA, YUJI |
分类号 |
A61K38/00;A61K31/198;A61K45/00;A61P19/02;A61P29/00;A61P43/00;C07C279/14;(IPC1-7):C07C279/14 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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