摘要 |
Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: - the linker is a bivalent straight or branched C1-C8 alkyl residu e, C3-C8 cycloalkyl, a phenylene or heterocyclic C4-C6 ring; - the G1 and G2 junctions, which can be the same or different, are - CO-, -COHN-, -CR2- grou ps in which R2 is hydrogen or a straight C1-C4 alkyl residue, or the G1-linker- G2 group is the -CO- group. The compounds of formula (I) have antiproliferative , antinflammatory, antiarthritic and antiviral activity.
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