发明名称 |
INDUCTION OF APOPTOSIS BY HIV-1 INFECTED MONOCYTIC CELLS |
摘要 |
The present invention generally relates to the treatment or inhibition of diseases associated with HIV-1 infection. In particular, the present invention identifies a protein, which is secreted by macrophages as a result of HIV infection. The secreted protein induces apoptosis in the neuronal cells, as well as T cells and B cell. The protein is specifically expressed in the neuronal tissue of HAD patients but not in the neuronal tissue of patients with non-HIV associated dementia. Methods and compositions for decreasing, inhibiting, or otherwise abrogating neuronal cell apoptosis that leads to HIV-1 associated dementia are described. |
申请公布号 |
WO2004045519(A3) |
申请公布日期 |
2005.08.18 |
申请号 |
WO2003US36382 |
申请日期 |
2003.11.13 |
申请人 |
SPERBER, KIRK;GELMAN, IRWIN, H. |
发明人 |
SPERBER, KIRK;GELMAN, IRWIN, H. |
分类号 |
A61K38/00;C07K14/47;C07K16/10;C12Q1/68;C12Q1/70;G01N33/569 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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