发明名称 |
SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN |
摘要 |
<p>The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.</p> |
申请公布号 |
WO2005075422(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
WO2005EP00793 |
申请日期 |
2005.01.27 |
申请人 |
RATIOPHARM GMBH;MARTIN, PIERRE;BERENS, ULRICH;BOUDIER, ANDREAS;DOSENBACH, OLIVER |
发明人 |
MARTIN, PIERRE;BERENS, ULRICH;BOUDIER, ANDREAS;DOSENBACH, OLIVER |
分类号 |
C07D209/16;C07D403/06;C07D521/00;(IPC1-7):C07D209/16 |
主分类号 |
C07D209/16 |
代理机构 |
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代理人 |
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地址 |
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