NAPHTHOQUINONE DERIVATIVE COMPOUND OR ITS PHARMACEUTICALLY PERMISSIBLE SALT AND Cdc25 PHOSPHATASE INHIBITOR AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To obtain a naphthoquinone derivative compound or its pharmaceutically permissible salt having high inhibitory activity against Cdc25 phosphatase and a Cdc25 phosphatase inhibitor and an antitumor agent containing the same as an active ingredient. SOLUTION: The naphthoquinone derivative compound represented by general formula (I) (R1and R2are each an alkoxy group; R3is a hydrogen atom; R4is an alkoxyalkyl group) or its pharmaceutically permissible salt has high inhibitory activity against Cdc25 phosphatase. Consequently, a substance containing the naphthoquinone derivative compound or its pharmaceutically permissible salt as an active ingredient is considered to be useful as a Cdc25 phosphatase inhibitor and an antitumor agent. COPYRIGHT: (C)2005,JPO&NCIPI