METHOD OF ALTERING THE PKA TYPE I SIGNALLING PATHWAY

摘要

The invention provides a method of altering the PKA type I signalling pathway in a cell comprising the step of administering an inhibitor, or a molecule encoding an inhibitor, which reduces or inhibits the binding between one or more of the following binding partners: i) ezrin and PKA type I, ii) ezrin and EBP50, and iii) EBP50 and Cbp/PAG. Also provided are inhibitor molecules for use in the method of the invention and pharmaceutical compositions comprising the inhibitors. Methods of treating disorders or diseases in which abnormal PKA type I signalling occurs such as HIV, AIDS,CVI or cancer using such inhibitors are also provided.