发明名称 |
Methods and compositions for the identification of anti-poxvirus agents |
摘要 |
The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an effect of the agent on a ubiquitin ligase activity of the p28 polypeptide. The effect of the agent may be determined using a variety of different cell based or biochemical assays, such as polyubiquitylation assays and cell viability assays. The invention also provides methods for modulating poxvirus pathogenicity in a cell, and methods of treating an individual infected with a poxvirus. The subject methods find use in a variety of drug discovery, research and military applications.
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申请公布号 |
US2005180994(A1) |
申请公布日期 |
2005.08.18 |
申请号 |
US20040975285 |
申请日期 |
2004.10.27 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
LU HENRY H.;HUANG JIANING;PAYAN DONALD G. |
分类号 |
A01N61/00;A61K39/275;C12P21/00;C12Q1/25;C12Q1/37;C12Q1/48;C12Q1/70;G01N;(IPC1-7):C12Q1/70 |
主分类号 |
A01N61/00 |
代理机构 |
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地址 |
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