发明名称 |
Process for preparing (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide |
摘要 |
<p>A method of preparation of (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of formula I and its use for production tamsulosin. A protective group is introduced to N-[(1R)-2(4-methoxyphenyl)-1-methylethyl]-N-[(1R)-1-phenylethyl)]amine and the resulting amide of formula IX is chlorosulfonated and the resulting sulfochloride is converted to a sulfonamide of formula X, from which the compound of formula I is obtained by hydrogenation.</p> |
申请公布号 |
CZ20040197(A3) |
申请公布日期 |
2005.08.17 |
申请号 |
CZ20040000197 |
申请日期 |
2004.02.05 |
申请人 |
ZENTIVA, A. S. |
发明人 |
HAJICEK JOSEF;SLAVIKOVA MARKETA |
分类号 |
C07C303/38;C07C303/40;C07C311/37;C07C311/46;(IPC1-7):C07C311/37 |
主分类号 |
C07C303/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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