发明名称 |
Process for the production of epothilones |
摘要 |
The invention concerns a process for the production of an epothilone of formula 9 <CHEM> wherein (i) an epothilone of formula 2a (scheme II) is converted into compound of formula 3a (scheme II), (ii) the compound of formula 3a is reacted with a compound of formula 6 (which has been formed by reacting a compound of formula 4 with a compound of formula 5; scheme II) to give a compound of formula 7 (scheme II), (iii)the compound of formula 7 is reacted in the presence of a Grubbs catalyst to give a compound of formula 8a (scheme II), (iv) the compound of formula 8a is converted into a compound of formula 8b (scheme II), and (v) compound of formula 8b is converted to a compound of formula 9 (scheme II). <??>Finally, the invention concerns compounds which are obtainable according to the process. <IMAGE> |
申请公布号 |
EP1564217(A2) |
申请公布日期 |
2005.08.17 |
申请号 |
EP20040019590 |
申请日期 |
2002.02.27 |
申请人 |
GESELLSCHAFT FUER BIOTECHNOLOGISCHE FORSCHUNG MBH(GBF) |
发明人 |
HOEFLE, GERHARD, PROF. DR.;KARAMA, USAMA |
分类号 |
C12P17/00;C07B61/00;C07C51/09;C07C51/353;C07C59/90;C07D277/20;C07D277/24;C07D277/30;C07D417/06;C07D493/04;C07F7/18;C12P7/62;C12P17/14;C12P17/18;(IPC1-7):C07D493/04 |
主分类号 |
C12P17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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