METHOD OF SCREENING FOR COMPOUNDS THAT INHIBIT THE ENZYMATIC ACTIVITY OF GWT1 GENE PRODUCT
摘要
The present invention enables screening for compounds that inhibit the transport of GPI-anchored proteins to fungal cell walls, using a simple assay for transacylation to GlcN-PI using membrane fraction expressing GWT1 protein. New antifungal agents can be created that inhibit the synthesis of fungal cell walls and also inhibit adhesion to host cells by inhibiting the transport of GPI-anchored proteins to fungal cell walls.
申请公布号
EP1564299(A1)
申请公布日期
2005.08.17
申请号
EP20030774148
申请日期
2003.11.21
申请人
EISAI CO., LTD.;NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY