发明名称 |
Stabilization of linear double-stranded DNA in the presence of exonucleases |
摘要 |
The present invention is directed at stabilizing linear polynucleotides against exonucleolytic attack. Adding to both ends of a double-stranded linear DNA a target sequence for a DNA-binding protein the double-stranded linear DNA with the two added target sequences has an increased stability against exonucleolytic attack when contacted with the DNA-binding protein.
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申请公布号 |
EP1564289(A1) |
申请公布日期 |
2005.08.17 |
申请号 |
EP20040002923 |
申请日期 |
2004.02.10 |
申请人 |
ROCHE DIAGNOSTICS GMBH;F. HOFFMANN-LA ROCHE AG |
发明人 |
BESIR, HUESEYIN DR. |
分类号 |
C12N15/09;C07H21/00;C07H21/04;C12N9/16;C12N15/10;C12N15/63;C12N15/68;C12P19/34;C12Q1/68;(IPC1-7):C12N15/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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