发明名称 |
COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF HIF-1 ALPHA |
摘要 |
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
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申请公布号 |
EP1562970(A2) |
申请公布日期 |
2005.08.17 |
申请号 |
EP20030768569 |
申请日期 |
2003.10.31 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
REICH, SAMUEL, JOTHAM;SURACE, ENRICO MARIA;TOLENTINO, MICHAEL, J. |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C07H21/04;A61K48/00;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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