发明名称 |
Process for synthesizing (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine |
摘要 |
<p>2-(7-Methoxy-1-naphthyl)acetonitrile (I) is produced by contacting 2-(7-methoxy-3,4-dihydro-1-naphthyl)acetonitrile (II) with a hydrogenation catalyst in the presence of an allylic compound. 2-(7-Methoxy-1-naphthyl)acetonitrile of formula (I) is produced by contacting 2-(7-methoxy-3,4-dihydro-1-naphthyl)acetonitrile of formula (II) with a hydrogenation catalyst in the presence of an allylic compound. An independent claim is also included for production of agomelatine, comprising producing (I) as above followed by reduction and reaction with acetic anhydride. [Image].</p> |
申请公布号 |
EP1564205(A1) |
申请公布日期 |
2005.08.17 |
申请号 |
EP20050290310 |
申请日期 |
2005.02.11 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
SOUVIE, JEAN-CLAUDE;GONZALEZ BLANCO, ISAAC |
分类号 |
C07B61/00;C07C231/02;C07C233/18;C07C253/30;C07C255/37;(IPC1-7):C07C253/30 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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