发明名称 |
Estrogenic compounds as anti-mitotic agents |
摘要 |
The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
|
申请公布号 |
US6930128(B2) |
申请公布日期 |
2005.08.16 |
申请号 |
US20030617150 |
申请日期 |
2003.07.10 |
申请人 |
THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
D'AMATO ROBERT JOHN;FOLKMAN MOSES JUDAH |
分类号 |
A61K31/05;A61K31/473;A61K31/56;A61K31/565;A61K31/567;A61K31/59;C07J1/00;C07J63/00;(IPC1-7):A61K31/00;C07C35/22;C07C211/00;C07C61/12;C07C69/74 |
主分类号 |
A61K31/05 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|