Cellular depolarization and regulation of matrix metalloproteinases

摘要

A mechanism is disclosed wherein depolarization of the cells associated with disease states, wherein matrix metalloproteinases are implicated as a contributor to the pathology of the disease state, and the subsequent regulation of certain proteins beneficially aids control of the matrix metalloproteinases. This initiating trigger can ultimately result in the down-regulation or up-regulation of matrix metalloproteinases. An example is given wherein matrix metalloproteinase 2 (MMP 2) is down-regulated.