发明名称 NOVEL CRYSTALLINE FORMS OF AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
摘要 Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4 ,5- dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11.beta.- hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairmen t. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment .
申请公布号 CA2553345(A1) 申请公布日期 2005.08.11
申请号 CA20052553345 申请日期 2005.01.21
申请人 MERCK & CO., INC. 发明人 LYNCH, JOSEPH E.;HUFFMAN, MARK A.;BEREZNITSKI, YURI;ZHAO, MATTHEW
分类号 C07D249/08;A61K31/4196 主分类号 C07D249/08
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