| 发明名称 |
Anti-inflammatory nitro- and thia- fatty acids |
| 摘要 |
The present invention relates to compounds of the general formula: NO<SUB>2</SUB>-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH<SUB>2</SUB>)<SUB>n</SUB>(COOH)<SUB>m </SUB>in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A' is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B' is (CH<SUB>2</SUB>)<SUB>j</SUB>(COOH)<SUB>k </SUB>in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
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| 申请公布号 |
US2005176817(A1) |
申请公布日期 |
2005.08.11 |
| 申请号 |
US20050072573 |
申请日期 |
2005.03.04 |
| 申请人 |
FERRANTE ANTONIO;EASTON CHRISTOPHER J.;XIA LING |
发明人 |
FERRANTE ANTONIO;EASTON CHRISTOPHER J.;XIA LING |
| 分类号 |
A61K8/30;A61K8/36;A61K8/40;A61K8/46;A61K31/04;A61K31/10;A61K31/19;A61K31/20;A61K31/202;A61K31/21;A61K31/335;A61P1/04;A61P1/18;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P17/00;A61P17/06;A61P25/00;A61P29/00;A61P31/00;A61P33/06;A61P35/00;A61P37/02;A61P37/06;A61P37/08;A61P39/06;A61P43/00;C07C17/16;C07C45/30;C07C205/02;C07C205/03;C07C205/14;C07C205/15;C07C205/50;C07C205/51;C07C317/44;C07C321/14;C07C321/18;C07C323/52;C07C409/40;(IPC1-7):A61K31/336;C07C23/04 |
主分类号 |
A61K8/30 |
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