PYRROLIDINE DERIVATIVES

摘要

[PROBLEMS] To provide compounds having DPP4-inhibiting activities and being useful as therapeutic and/or preventive agents for diseases in which DPP4 intervenes. [MEANS FOR SOLVING PROBLEMS] Compounds represented by the general formula (I); salts, solvates or N-oxides of the same; and prodrugs of them: (I) (wherein R is hydrogen or cyano; R<1a>, R<1b>, R<1c>, R<1d> and R<x> are each independently hydrogen or a substituent; and n is an integer of 0 to 7). The compounds represented by the general formula (I), salts, solvates or N-oxides of the same, and prodrugs of them have DPP4-inhibiting activities and are therefore useful as therapeutic and/or preventive agents for diseases in which DPP4 intervenes, for example, diabetes (such as postprandial hyperglycemia and type II diabetes).