OSTEOBLAST FACTOR(S) THAT REGULATES HUMAN PROSTATE CANCER MIGRATION TO AND INVASION OF BONE

摘要

Human osteogenic cells secrete biological activities that stimulate cancer cells to migrate to and/or invade tissues. Conditioned medium (CM) produced by human pre-osteoblasts and osteoblasts induced migration and tissue invasion of human prostate cancer cells. Thus, conditioned media and/or proteins isolated therefrom may be used to identify metastasis-inducing factors. Also described are methods of identifying an inhibitor of such factors.