PROCESS FOR PREPARATION OF SUBSTITUTED AMINO ALCOHOLS

摘要

There is provided a process for the preparation of substituted amino alcohols HO-(CH2)n-NR<1>R<2> from haloalcohols HO-(CH2)n-X, where X is Cl, Br or I, bz reaction with an amine HNR<1>R<2>, in water as solvent at a temperature range of about 20°C to about 90°C optionally in the presence of a catalytic amount of an iodide source3 metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.