METHOD OF SCREENING COMPOUND SAFE TO GASTRIC MUCOSA

摘要

A screening method for selecting a compound being safe to gastric mucosa and having less side effect of gastrointestinal tract lesion or a salt thereof, especially a nonsteroidal antiinflammatory compound or a salt thereof. There is provided a method of screening a compound safe to gastric mucosa, especially a nonsteroidal antiinflammatory compound, characterized in that using a liposome having a fluorescent dye, especially calcein, sealed therein and having a cell membrane model constituted of a phospholipid, such as phosphatidylcholine, phosphatidylglycerol, phosphatidylserine or phosphatidylinositol, the liposome is reacted with a test compound and thereafter the degree of leakage of fluorescent dye from the liposome is estimated.