发明名称 |
A PROCESS FOR PREPARING DULOXETINE AND INTERMEDIATES FOR USE THEREIN |
摘要 |
A process for preparing (+)duloxetine, or an acid addition salt thereof, which process comprises resolving racemic (±)duloxetine with a chiral acid so as to obtain a salt of the chiral acid and (+)duloxetine, substantially free of (-)duloxetine; and (ii) if desired, converting the salt prepared in step (i) to the free base or another acid addition salt as appropriate. The process for preparing (+)duloxetine, or an acid addition salt thereof, can further comprise an O-alkylation intermediate process step which is carried out in the presence of a base and a phase transfer catalyst.
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申请公布号 |
WO2004056795(A8) |
申请公布日期 |
2005.08.11 |
申请号 |
WO2003GB05357 |
申请日期 |
2003.12.10 |
申请人 |
CIPLA LTD;RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO;WAIN, CHRISTOPHER, PAUL |
发明人 |
RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO |
分类号 |
A61P25/24;C07D333/20;(IPC1-7):C07D333/20;A61K31/381 |
主分类号 |
A61P25/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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