METHOD OF SCREENING FOR NEW DRUGS

摘要

A method for identifying compounds that are effective in modulating the binding of nucleophosmin to Bax (Bcl-2-associated X protein). Nucleophosmin has been found to regulate the activity of Bax. The interaction between Bax and nucleophosmin is used in a method for the screening of new drugs for the treatment of disorders that involve Bax-mediated cell death. A kit for assaying the interaction between Bax and nucleophosmin is also provided. Compounds identified by the aforementioned method are used for the manufacture of medicaments for treating cerebral and myocardial ischaemic injury, neonatal hypoxic brain injury, traumatic brain injury and other neurological disorders.