发明名称 |
CRYSTALS OF AN AURORA-A TPX2 COMPLEX, TPX2 BINDING SITE OF AURORA-A, AURORA-A LIGANDS AND THEIR USE |
摘要 |
The present invention relates to crystals of phosphorylated Aurora-A kinase fragment alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands, in particular allosteric inhibitors of Aurora-A, that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivatives.The present invention relates to crystals of phosphorylated Aurora-A kinase alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivative. |
申请公布号 |
WO2005040368(A3) |
申请公布日期 |
2005.08.11 |
申请号 |
WO2004EP11381 |
申请日期 |
2004.10.11 |
申请人 |
EMBL;CONTI, ELENA;BAYLISS, RICHARD;SCHULTZ, CARSTEN;VERNOS, ISABELLE;SARDON, TERESA |
发明人 |
CONTI, ELENA;BAYLISS, RICHARD;SCHULTZ, CARSTEN;VERNOS, ISABELLE;SARDON, TERESA |
分类号 |
C07D209/42;C07K14/47;C12N9/12 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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