Amorphous form of 2-n-butyl-3-((2-(1h-tetrazol-5-yl)([1,1'-biphenyl)-4-yl)methyl)-1, 3-diazaspiro(4,4')non-1-en-4-one

摘要

The present invention relates to a novel amorphous form of 2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one and to a process for preparation thereof. Irbesartan (2-n-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4] non-1-en-4-one), represented by the following formula (I), is a non-peptide angiotensin-II antagonist. By inhibiting the action of angiotensin-II on its receptors, this compound prevents the increase in blood pressure produced by the hormone-receptor interactions and is hence used in the treatment of cardiovascular complaints such as hypertension and heart failure.