摘要 |
The invention relates to the compounds of formula (I), which are suitable for producing drugs for the prophylaxis and therapy of diseases, whereby the course thereof involves the increased activity of matrix metalloproteinases. Diseases belonging thereto are degenerative joint diseases, for example, osteo-arthroses, spondyloses, chondroporosis after articulation injury or a long duration of articulation immobilization after meniscus or patella injury or torn ligaments, or a disease of the connective tissue, such as collagenoses, periodontal diseases, problems with healing wounds, or a chronic disease of the locomotor system, such as inflammatory, immunological or metabolic-related acute or chronic arthrites, arthropathies, myalgies or troubles of the bone metabolism, or ulceration, atherosclerosis or stenosis. The compounds of formula (I) are also suitable for treating inflammatory diseases or cancers, metastatic tumors, cachexia, anorexia, heart failure or septic shock and in the prophylaxis of myocardial and cerebral infarction. |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH;SCHUDOK, MANFRED;MATTER, HANS;HOFMEISTER, ARMIN |
发明人 |
SCHUDOK, MANFRED;MATTER, HANS;HOFMEISTER, ARMIN |