发明名称 |
COMPOSITIONS COMPRISING MELITTIN-DERVED PEPTIDES AND METHODS FOR THE POTENTIATION OF IMMUNE RESPONSES AGAINST TARGET ANTIGENS |
摘要 |
The present invention provides novel adjuvant systems that reduce the risk of toxic side effects associated with the use of known adjuvants while providing powerful stimulation of immune responses against target antigens. These novel adjuvant systems are based on the honey bee venom melittin or specific cationic peptides derived from melittin and ae capable of eliciting strong immune responses against target antigens. To further enhance their immunogenicity they can be optionally combined with synthetic oligonucleotides (ODNs) lacking any immunostimulatory sequences such as CpG motifs. |
申请公布号 |
WO2005049647(A3) |
申请公布日期 |
2005.08.11 |
申请号 |
WO2004EP12548 |
申请日期 |
2004.11.05 |
申请人 |
PEVION BIOTECH LTD.;ZURBRIGGEN, RINALDO |
发明人 |
ZURBRIGGEN, RINALDO |
分类号 |
A61K9/127;A61K35/64;A61K39/00;A61K39/39;A61K48/00;C07K14/435 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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