发明名称 |
3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS |
摘要 |
<p>Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRalpha, the compounds described herein which are capable of modulating ERRalpha activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson's disease and Alzheimer's disease. Formula (I). The substituents are defined in the claims.</p> |
申请公布号 |
WO2005072731(A1) |
申请公布日期 |
2005.08.11 |
申请号 |
WO2005US02736 |
申请日期 |
2005.01.28 |
申请人 |
X-CEPTOR THERAPEUTICS, INC.;BUSCH, BRETT;JOHNSON, ALAN, T.;MARTIN, RICHARD;MOHAN, RAJU;STEVENS, WILLIAM, C., JR. |
发明人 |
BUSCH, BRETT;JOHNSON, ALAN, T.;MARTIN, RICHARD;MOHAN, RAJU;STEVENS, WILLIAM, C., JR. |
分类号 |
C07D271/10;C07D271/113;C07D277/46;C07D285/12;C07D285/135;(IPC1-7):A61K31/433;A61P25/22;A61K31/425;A61P25/30;A61P25/28;A61P25/24;A61K31/426;A61P19/02;A61P35/00 |
主分类号 |
C07D271/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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