PRODUCTION OF HOST CELLS CONTAINING MUTIPLE INTEGRATING VECTORS BY SERIAL TRANSDUCTION
摘要
The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector comprising an exogenous gene and methods of making such host cells by serial transduction or transfection. The present invention further provides methods of expressing increased levels of protein in host cells using such vectors.
申请公布号
WO2005072129(A2)
申请公布日期
2005.08.11
申请号
WO2005US01165
申请日期
2005.01.14
申请人
GALA DESIGN, INC.;BLECK, GREGORY, T.;BREMEL, ROBERT, D.;MILLER, LINDA, U.
发明人
BLECK, GREGORY, T.;BREMEL, ROBERT, D.;MILLER, LINDA, U.