发明名称 |
СПОСОБЫ И ЛЕКАРСТВЕННЫЕ ФОРМЫ ДЛЯ КОНТРОЛИРУЕМОЙ ДОСТАВКИ ПАЛИПЕРИДОНА |
摘要 |
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form. |
申请公布号 |
RU2005102105(A) |
申请公布日期 |
2005.08.10 |
申请号 |
RU20050102105 |
申请日期 |
2003.07.28 |
申请人 |
АЛЗА КОРПОРЕЙШН (US) |
发明人 |
ЯМ Нойми В. (US);РЕЙЕС Айрэн (US);ДАВАР Нипун (US);АЙЕР Атул Д. (US);ЛИ Джули (US) |
分类号 |
C07D471/04;A61K9/00;A61K9/24;A61K9/30;A61K9/62;A61K31/506;A61K31/519;A61P25/18;A61P25/22;A61P25/24 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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