发明名称 PHOTOSENSIBILIZING AGENT, LIPOSOMAL FORMULATION OF PHOTOSENSIBILIZING AGENT AND METHOD FOR CARRYING OUT PHOTODYNAMIC THERAPY
摘要 FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to a photosensibilizing compound representing phenylthio-substituted derivative of phthalocyanine of the general formula (I): wherein R means hydrogen atom (H), t-C4H9; M means HH, AlOH, Zn. Also, invention relates to its liposomal formulation representing the composition of mixture of lipids (lecithin, cholesterol, cardiolipin) and a photosensibilizing agent, and to a method for carrying out the photodynamic therapy using this formulation. Photosensibilizing agents show high elimination rate from normal tissues, provide the deep therapeutic effect on tumor tissues, non-toxic properties and perspective for their using in oncology and other branches of medicine. ^ EFFECT: valuable medicinal properties of compound. ^ 4 cl, 3 dwg, 9 ex
申请公布号 RU2257898(C1) 申请公布日期 2005.08.10
申请号 RU20040108103 申请日期 2004.03.22
申请人 发明人 BARYSHNIKOV A.JU.;BORISOVA L.M.;VOROZHTSOV G.N.;GERASIMOVA G.K.;DAVYDOV M.I.;DERKACHEVA V.M.;KOKAREVA V.I.;KUBASOVA I.JU.;LOSHCHENOV V.B.;LUZHKOV JU.M.;LUK'JANETS E.A.;MEEROVICH G.A.;MEEROVICH I.G.;OBOROTOVA N.A.;POLOZKOVA A.P.;SMIRNOVA Z.S.;STRATONNIKOV A.A.
分类号 A61K31/409;A61K9/127;A61P35/00 主分类号 A61K31/409
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