| 发明名称 |
ACTIVITY-DEPENDENT NEUROTROPHIC FACTOR |
| 摘要 |
The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increases the survival of spinal cord neuron cells, cerebral cortical cells and hippocampal neuron cells which has a molecular weight of 16,000 to 18,000 Daltons as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and a basic pI of about 8.1. The protein of the present invention can be used in the treatment of neurological deficiencies and for the prevention of AIDS related neuronal cell death.
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| 申请公布号 |
CA2109098(C) |
申请公布日期 |
2005.08.09 |
| 申请号 |
CA19922109098 |
申请日期 |
1992.04.22 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRE TAR |
发明人 |
BRENNEMAN, DOUGLAS E.;GOZES, ILLANA |
| 分类号 |
A61K38/00;A61K39/395;A61P25/00;A61P31/12;A61P31/18;C07K1/00;C07K14/435;C07K14/475;C07K14/52;C07K16/00;C07K16/22;C07K16/24;C12P21/08;(IPC1-7):C07K14/48;C07K7/06;A61K38/08;C07K7/08;A61K38/10;A61K38/18 |
主分类号 |
A61K38/00 |
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