摘要 |
There is disclosed an advantageous mixed acid anhydride production method of formula (1): <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>C(O)OY(O)<SUB>n</SUB>(R<SUP>2</SUP>)<SUB>p</SUB> (1)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>1</SUP>, R<SUP>2 </SUP>and Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2); <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>COOH (2)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>1 </SUP>denotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3); <?in-line-formulae description="In-line Formulae" end="lead"?>(R<SUP>2</SUP>)<SUB>p</SUB>Y(O)<SUB>n</SUB>X (3)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>2 </SUP>denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.
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