发明名称 BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS
摘要 The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and R3 is amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by histone deacetylase.
申请公布号 PL372967(A1) 申请公布日期 2005.08.08
申请号 PL20030372967 申请日期 2003.04.02
申请人 ASTRAZENECA AB 发明人 STOKES ELAINE SOPHIE ELIZABETH;ROBERTS CRAIG ANTHONY;WARING MICHAEL JAMES
分类号 C07D251/14;A61K31/341;A61K31/426;A61K31/427;A61K31/435;A61K31/4365;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/444;A61K31/445;A61K31/4465;A61K31/4525;A61K31/453;A61K31/454;A61K31/47;A61K31/4709;A61K31/4725;A61K31/495;A61K31/4965;A61K31/497;A61K31/505;A61K31/506;A61K31/519;A61K31/53;A61K31/5375;A61K31/5377;A61P7/06;A61P25/14;A61P35/00;A61P43/00;C07D211/34;C07D213/56;C07D213/74;C07D215/12;C07D237/08;C07D239/26;C07D239/42;C07D241/12;C07D241/18;C07D241/20;C07D251/18;C07D277/20;C07D277/24;C07D277/30;C07D295/14;C07D295/155;C07D307/54;C07D401/04;C07D401/06;C07D401/12;C07D403/12;C07D405/06;C07D407/06;C07D409/04;C07D413/04;C07D413/06;C07D417/06;C07D487/04;C07D495/04 主分类号 C07D251/14
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