A NOVEL HANSENULA POLYMORPHA GENE CODING FOR alpha1,6- MANNOSYLTRANSFERASE AND PROCESS FOR THE PRODUCTION OF RECOMBINANT GLYCOPROTEINS WITH HANSENULA POLYMORPHA MUTANT STRAIN DEFICIENT IN THE SAME GENE

摘要

Disclosed are a novel Hansenula polymorpha gene coding for α-1,6-mannosyltransferase initiating outer chain elongation, an H. polymorpha mutant strain having a deficiency in the gene, and a process for producing a recombinant glycoprotein using such a mutant strain.