发明名称 |
SILK BIOMATERIALS AND METHODS OF USE THEREOF |
摘要 |
The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo. |
申请公布号 |
EP1558444(A2) |
申请公布日期 |
2005.08.03 |
申请号 |
EP20030761306 |
申请日期 |
2003.06.24 |
申请人 |
TUFTS UNIVERSITY;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
KAPLAN, DAVID, L.;JIN, HYOUNG-JOON;RUTLEDGE, GREGORY;FRIDRIKH, SERGEI |
分类号 |
B32B27/06;A61L27/22;A61L27/36;A61L27/44;A61L27/48;C07K14/435;C08H1/00;C08J;C08L89/00;D01D5/00;D01F4/02;D01F6/88;D02G3/04;D06M13/17;D06M15/00;D06M15/03;D06M15/11 |
主分类号 |
B32B27/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|