发明名称 |
Delivery construct for antisense nucleic acids and methods of use |
摘要 |
A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy.
|
申请公布号 |
US6924096(B2) |
申请公布日期 |
2005.08.02 |
申请号 |
US19980163289 |
申请日期 |
1998.09.29 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
DIETZ HARRY C. |
分类号 |
A61K38/00;A61K48/00;C12N15/113;(IPC1-7):C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|