发明名称 |
Method of modulating the activity of calcium channels in cardiac cells and reagents therefor. |
摘要 |
The present invention relates generally to novel peptides that are capable of modulating the activity of calcium channels in cardiac cells. More specifically, the present invention provides a method of modulating the activity of a cardiac calcium channel comprising contacting a cardiac ryanodine receptor (RyR2) with an amount of a fragment of a dihydropyridine receptor (DHPR) polypeptide sufficient to modulate the activity of said RyR2, and determining the activity of said calcium channel. The inventive method is useful for the treatment of a range of disorders and diseases associated with cardiac dysfunction, particularly those diseases and disorders involving reduced cardiac output and/or aberrant excitation-contraction coupling, calcium overload, or calcium leakage, in cardiac cells. |
申请公布号 |
ZA200309727(B) |
申请公布日期 |
2005.08.01 |
申请号 |
ZA20030009727 |
申请日期 |
2003.12.15 |
申请人 |
THE AUSTRALIAN NATIONAL UNIVERSITY |
发明人 |
ANGELA FAY DULHUNTY;MARCO GIOVANI CASAROTTO |
分类号 |
G01N33/50;A61K38/00;A61K38/17;A61P9/00;A61P9/04;A61P9/06;A61P9/10;A61P29/00;A61P31/04;A61P43/00;C07K14/435;C07K14/705;G01N33/15;G01N33/566;G01N33/68;G01N33/94 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|