3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors

摘要

Disclosed are compounds of formula (I), wherein: R1 is H, halo, alkyl, haloalkyl, cycloalkyl, heteroalicyclic, hydroxy, alkoxy, -C(O)R8, -NR9R10 or -C(O)NR12R13, R2 is H, halo, alkyl, trihalomethyl, hydroxy, alkoxy, cyano, -NR9R10, -NR9C(O)R10, -C(O)R8, -S(O)2NR9R10 or - SO2R14, R3, R4 and R5 are independently H or alkylo, Z is aryl, heteroaryl, heterocycle, or -NR15R16 wherein R15 and R16 are independently H or alkyl, or R15 and R16 together form a heterocycloamino group, R6 is H or alkyl, R7 is H, alkyl, aryl, heteroaryl, or -C(O)R17, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the modulation of the catalytic activity of a protein kinase.