| 摘要 |
The disclosure relates to a peptide comprising: a) between 6 and 40 contiguous amino acid residues from the amino acid sequence of "region 1" of a Bordetella pertussis pertactin; and b) a total of between 6 and 100, preferably between 6 and 50 amino acid residues; or an analog of such a peptide; optionally in the form of a salt acceptable for pharmaceutical and/or veterinary purposes. The disclosure also relates to a polypeptide having the amino acid sequence of a pertactin from which, compared to the sequence of said pertactin: a) the amino acid residues that form the so-called "region 1" have been at least partly, and preferably essentially completely removed; and/or from which, b) the amino acid residues that form the so-called "region 2" have been at least partly, and preferably essentially completely removed. The disclosure further relates to a pharmaceutical composition, and in particular a vaccine against (at least) Bordetella pertussis and/or Bordetella parapertussis, comprising the peptide and/or the polypeptide mentioned above. Also disclosed is an antibody, generated/elicited against such a peptide and/or polypeptide, and to a pharmaceutical and/or veterinary composition comprising such an antibody.
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